Detect guideline-recommended genomic biomarkers
across all 4 major alteration classes.¹

Genes containing alterations reported by Guardant360 CDx¹

Point Mutations and InDels (Complete or Critical Exon Coverage in 74 Genes)
ΑΚΤ1	CDH1	FGFR2	KRAS	NPM1	RIT1
ALK	CDK4	FGFR3	MAP2K1	NRAS	ROS1
APC	CDK6	GATA3	MAP2K2	NTRK1	SMAD4
AR	CDK12	GNA11	MAPK1	NTRK3	SMO
ARAF	CDKN2A	GNAQ	MAPK3	PDGFRA	STK11
ARID1A	CTNNB1	GNAS	MET	PIK3CA	TERT
ATM	DDR2	ΗΝF1Α	MLH1	PTEN	TP53
BRAF	EGFR	HRAS	MPL	PTPN11	TSC1
BRCA1	ERBB2	IDH1	MTOR	RAF1	VHL
BRCA2	ESR1	IDH2	MYC	RB1
CCND1	EZH2	JAK2	NF1	RET
CCND2	FBXW7	JAK3	NFE2L2	RHEB
CCNE1	FGFR1	KIT	NOTCH1	RHOA

Amplifications (18 Genes)
AR	FGFR1
BRAF	FGFR2
CCND1	KIT
CCND2	KRAS
CCNE1	MET
CDK4	MYC
CDK6	PDGFRA
EGFR	PIK3CA
ERBB2	RAF1

Fusions (6 Genes)
ALK
FGFR2
FGFR3
NTRK1
RET
ROS1

Microsatellite
Instability (MSI-High)

Guardant360^® Liquid is a blood-based advanced-stage solid tumor guideline-complete^* comprehensive genomic profiling test powered by the Guardant Infinity^TM platform that interrogates 744 genes and includes TMB, MSI status, methylation-based tumor fraction, and other novel test features.²

LDT Reportable Range SNV / Indel (739 genes)
ABCB1	ABL1	ABL2	ABRAXAS1	ACVR1	ACVR1B	ACVR2A	ADARB2	ADGRA2	ADGRG4	AFDN	AGGF1
AIP	AKT1	AKT1S1	AKT2	AKT3	ALB	ALK^‖	ALOX12B	ALOX15B	ALOX5	AMER1	APC^††
APEX1	APLNR	AR^#	ARAF	ARFRP1	ARHGAP35	ARID1A^††	ARID1B^††	ARID2	ASXL1	ATM^‖**††	ATMIN
ATR^††	ATRX	AURKA	AURKB	AURKC	AXIN1	AXIN2	AXL	B2M^††	BABAM1	BABAM2	BAP1
BARD1	BCL2	BCL2L1	BCL2L2	BCL6	BCOR	BCORL1	BCR	BIRC5	BLM	BMPR1A	BRAF^#‖
BRCA1^‖**††	BRCA2^‖**††	BRCC3	BRD2	BRD3	BRD4	BRIP1^††	BSG	BTG1	BTG2	BTK	BUB1B
C9orf78	CALR	CARD11	CASP8	CASR	CAV1	CBFB	CBL	CBLB	CCAR1	CCN6	CCNA2
CCNB1	CCND1^#	CCND2^#	CCND3	CCNE1^#	CCNE2	CD274	CD276	CD74	CD79A	CD79B	CDC27
CDC5L	CDC7	CDC73	CDH1^††	CDH6	CDK11A	CDK12^‖**††	CDK4^#	CDK6^#	CDK7	CDK8	CDKN1A
CDKN1B^††	CDKN1C	CDKN2A^‖**††	CDKN2B	CDKN2C	CEBPA	CELF4	CEP295	CFAP20	CHD4	CHEK1^††	CHEK2^‖**††
CIC	CMTM4	CMTM6	CNOT3	CREBBP	CRKL	CRTC1	CSF1R	CSF3R	CTC1	CTCF	CTLA4
CTNNA1	CTNNB1	CUL3	CUL4A	CUX1	CWC22	CXCR4	CYLD	CYP17A1	CYP19A1	CYP2C19	CYP2D6^¶¶
CYP3A4	DAXX	DCUN1D1	DDIT3	DDR1	DDR2	DDX17	DDX18	DDX27	DDX3X	DDX41	DEPDC5
DEPTOR	DHX15	DHX16	DHX36	DHX9	DICER1	DIS3L2	DLL4	DNAJB1	DNMT1	DNMT3A	DNMT3B
DOT1L	DPYD^¶¶	DUSP4	DYNLL1	DYRK2	E2F3	EBV^##	ECT2L	EFTUD2	EGFR^#‖	EIF1AX	EIF4A1
EIF4A2	EIF4A3	EIF4B	EIF4E	EIF4E2	ELAVL1	ELAVL2	ELF3	ELOC	EML4	EMSY	EP300
EPCAM	EPHA3	EPHA5	EPHA7	EPHB1	ERBB2^#	ERBB3	ERBB4	ERCC1	ERCC2	ERCC3	ERCC4
ERCC5	ERCC6	ERCC6L2	ERCC8	EREG	ERF	ERG	ERRFI1	ESR1^#‖	ETS1	ETV1	ETV4
ETV5	ETV6	EWSR1	EXO1	EZH1	EZH2	FAAP100	FAAP20	FAAP24	FANCA^††	FANCB	FANCC
FANCD2	FANCE^††	FANCF^††	FANCG^††	FANCI	FANCL^††	FANCM	FAS	FAT1	FBXW7	FCGR2A	FCGR3A
FEN1	FGF1	FGF10	FGF12	FGF14	FGF19	FGF2	FGF23	FGF3	FGF4	FGF5	FGF6
FGF7	FGF8	FGF9	FGFR1^#‖	FGFR2^#‖	FGFR3^‖	FGFR4	FH	FLCN	FLT1	FLT3	FLT4
FOXA1	FOXL2	FOXO1	FOXP1	FRS2	FUBP1	FUBP3	FUS	FYN	FZD1	FZD10	FZD2
FZD3	FZD4	FZD5	FZD6	FZD7	FZD8	FZD9	GAS6	GATA1	GATA2	GATA3	GATA4
GATA6	GEN1	GID4	GLI1	GNA11	GNA13	GNAQ	GNAS	GPATCH8	GPC3	GREM1	GRIN2A
GSK3B	GSTM1	GSTP1	H3-4	H3F3A	HACD4	HDAC2	HDAC6	HELQ	HES1	HEY1	HEYL
HGF	HNF1A	HNRNPDL	HOXB13	HRAS	HSD3B1	HSP90AA1	ICOSLG	ID3	IDH1	IDH2	IDO1
IFNG	IFNGR1	IFNGR2	IFNW1	IGF1	IGF1R	IGF2	IGF2BP3	IGF2R	IKBKE	IKZF1	IL1R1
IL2RA	IL2RB	IL2RG	IL7R	INHBA	INPP4B	INTS6L	IRF1	IRF2	IRF4	IRS2	JAK1
JAK2	JAK3	JUN	KAT6A	KAT6B	KDM4A	KDM5A	KDM5B	KDM5C	KDM6A	KDR	KEAP1^‖**††
KIN	KIT^#	KLF4	KLHL6	KLHL9	KMT2A	KMT2B	KMT2C	KMT2D	KNSTRN	KRAS^#	LATS1
LGR4	LGR5	LGR6	LIG1	LIG4	LMO1	LRP1B	LRP2	LRP5	LRP6	LTK	LYN
LZTR1	MAD2L2	MALT1	MAP2K1	MAP2K2	MAP2K4	MAP3K1	MAP3K13	MAP4K3	MAPK1	MAPK3	MAPKAP1
MARK2	MAX	MCL1	MDC1	MDM2	MDM4	MED12	MEF2B	MEN1	MERTK	MET^‖#	MGA
MGMT^‡‡	MITF	MKNK1	MLH1^††	MLH3	MLST8	MPL	MRAS	MRE11	MSH2^††	MSH3	MSH6^††
MTAP^‖**††	MTHFR	MTOR	MUTYH^††	MYB	MYC^#	MYCL	MYCN	MYD88	MYOD1	NAB2	NBN
NCOR1	NCR1	NCR3	NEGR1	NELFE	NF1^††	NF2^††	NFE2L2	NFKBIA	NHEJ1	NKX2-1	NOTCH1
NOTCH2	NOTCH3	NOTCH4	NOVA1	NPM1	NPRL2	NPRL3	NRAS	NRG1^‖	NSD1	NSD2	NSD3
NSRP1	NTHL1	NTRK1^‖	NTRK2^‖	NTRK3^‖	NUMA1	NUMB	NUP93	NUTM1	P2RY8	PABPC1	PAK1
PAK3	PALB2^‖**††	PARG	PARP1	PARP2	PAX3	PAX5	PAX7	PAX8	PAXIP1	PBRM1^††	PCBP1
PCBP2	PCDH15	PDCD1	PDCD1LG2	PDE7A	PDGFRA^#	PDGFRB	PDK1	PDPK1	PHF6	PHLPP1	PHLPP2
PHOX2B	PIAS4	PIK3C2B	PIK3CA^#	PIK3CB	PIK3CD	PIK3CG	PIK3R1	PIK3R2	PIK3R3	PIM1	PIN1
PKM	PLCG2	PLEKHS1	PLRG1	PMS1	PMS2^††	POLA1	POLD1	POLE^††	POLH	POLQ	POT1
POU2F2	PPARG	PPIG	PPM1D	PPP2CA	PPP2R1A	PPP2R2A	PPP3CA	PPP6C	PRDM1	PREX1	PREX2
PRKAR1A	PRKCI	PRKDC	PRKN	PRMT5	PRPF40B	PRPF4B	PSENEN	PSMB10	PSMB8	PSMB9	PTCH1
PTDSS1	PTEN^‖**††	PTPN11	PTPN2	PTPRD	PTPRS	PTPRT	QKI	RAB35	RAC1	RAD18	RAD21
RAD50^††	RAD51^††	RAD51B	RAD51C^‖**††	RAD51D^‖**††	RAD52	RAD54L	RAET1E	RAF1^#	RARA	RASA1	RB1^‖**††
RBBP6	RBM10	RBMX	RECQL	RECQL4	RET^‖	REV3L	RGS1	RHEB	RHOA	RHOB	RICTOR
RIF1	RILPL1	RIT1	RNASEH2B	RNF43	ROBO1	ROBO2	ROS1^‖	RPA1	RPS27A	RPS6KA3	RPS6KB1
RPS6KB2	RPTOR	RRAGC	RSPO1	RSPO2	RSPO4	RUNX1	RUNX1T1	RXRA	RYBP	SAMHD1	SDC4
SDHA^††	SDHAF2	SDHB^††	SDHC^††	SDHD^††	SEM1	SERPINB3	SERPINB4	SESN2	SETD2	SF3B1	SF3B3
SH2D1A	SHLD1	SHLD2	SLC34A2	SLFN11	SLIT2	SMAD2	SMAD3	SMAD4^††	SMARCA2	SMARCA4	SMARCAL1
SMARCB1	SMARCD1	SMARCE1	SMC1A	SMC3	SMO	SNCAIP	SOCS1	SOCS3	SOS1	SOX10	SOX17
SOX2	SOX9	SPEN	SPOP	SRC	SRSF2	SRY	SS18	STAG2	STAT1	STAT3	STAT4
STK11^‖**††	STK19	STK40	STN1	SUFU	SYK	SYNCRIP	TACSTD2 (TROP2)	TAF1L	TAP1	TAP2	TAPBP
TBC1D7	TBX3	TCERG1	TCF7L2	TEK	TEN1	TENT5C	TERT^¶	TET1	TET2	TFE3	TFRC
TGFBR1	TGFBR2	THRAP3	TIA1	TIPARP	TMEM127	TMPRSS2	TNFAIP3	TNFRSF14	TNFRSF1A	TNK2	TNPO1
TOP1	TOP2A	TOPAZ1	TP53^††	TP53BP1	TP63	TP73	TPMT^¶¶	TRAF2	TRAF3	TRAF7	TRIM24
TRIP13	TSC1	TSC2^††	TSHR	TSHZ2	TYMP	TYMS	TYRO3	U2AF1	UBE2T	UGT1A1^¶¶	UIMC1
ULBP1	ULBP3	USP28	USP7	USP9X	VEGFA	VEGFB	VHL	VIRMA	WBP11	WEE1	WRN
WT1	WWP1	XBP1	XPA	XPC	XPO1	XRCC1	XRCC2	XRCC3	XRCC4	XRCC5	XRCC6
YAP1	YES1	ZC3H13	ZC3H18	ZC3H4	ZMYM3	ZNF217	ZNF703	ZNRF3	ZRSR2

^*Refers to emerging biomarkers that are in guidelines.

^¶ Includes TERT promoter region.

^# Includes CNAs.

^‖ Includes Fusions/Rearrangements.

^** Includes Copy Number Losses.

^†† Includes Promoter Methylation.

^‡‡ Promoter Methylation only.

^§§ HLA alleles.

^¶¶ Pharmacogenomic results.

^## Virus.

^HR High-risk.

CHIP filter is based on a proprietary algorithm that identifies variants that are potentially derived from clonal hematopoiesis.

References:
1. Guardant360® CDx Specification Sheet. Guardant Health, Inc. Palo Alto, CA. July 2025.
2. Guardant360® Liquid Specification Sheet. Guardant Health, Inc. Palo Alto, CA. July 2024.

Detect guideline-recommended genomic biomarkers across all 4 major alteration classes.1

Guardant360® Liquid is a blood-based advanced-stage solid tumor guideline-complete* comprehensive genomic profiling test powered by the Guardant InfinityTM platform that interrogates 744 genes and includes TMB, MSI status, methylation-based tumor fraction, and other novel test features.2

Detect guideline-recommended genomic biomarkers
across all 4 major alteration classes.¹

Guardant360^® Liquid is a blood-based advanced-stage solid tumor guideline-complete^* comprehensive genomic profiling test powered by the Guardant Infinity^TM platform that interrogates 744 genes and includes TMB, MSI status, methylation-based tumor fraction, and other novel test features.²