Guardant360CDx

Detect guideline-recommended genomic biomarkers
across all 4 major alteration classes.1

Genes containing alterations reported by Guardant360 CDx 1

Point Mutations and InDels
(Complete or Critical Exon Coverage in 74 Genes)
ΑΚΤ1 CDH1 FGFR2 KRAS NPM1 RIT1
ALK CDK4 FGFR3 MAP2K1 NRAS ROS1
APC CDK6 GATA3 MAP2K2 NTRK1 SMAD4
AR CDK12 GNA11 MAPK1 NTRK3 SMO
ARAF CDKN2A GNAQ MAPK3 PDGFRA STK11
ARID1A CTNNB1 GNAS MET PIK3CA TERT
ATM DDR2 ΗΝF1Α MLH1 PTEN TP53
BRAF EGFR HRAS MPL PTPN11 TSC1
BRCA1 ERBB2 IDH1 MTOR RAF1 VHL
BRCA2 ESR1 IDH2 MYC RB1
CCND1 EZH2 JAK2 NF1 RET
CCND2 FBXW7 JAK3 NFE2L2 RHEB
CCNE1 FGFR1 KIT NOTCH1 RHOA
Amplifications
(18 Genes)
AR FGFR1
BRAF FGFR2
CCND1 KIT
CCND2 KRAS
CCNE1 MET
CDK4 MYC
CDK6 PDGFRA
EGFR PIK3CA
ERBB2 RAF1
Fusions
(6 Genes)
ALK
FGFR2
FGFR3
NTRK1
RET
ROS1
Microsatellite
Instability (MSI-High)
Guardant360

Guardant360 is a comprehensive liquid profiling test that
interrogates 739 genes and includes TMB, MSI status, and
methylation-based tumor fraction. 2

LDT Reportable Range
SNV / Indel (739 genes)
ABCB1 BRCC3 CREBBP ELOC FGF5 HGF LGR6 NF1 PIK3R1 RARA SMARCAL1 TOP2A
ABL1 BRD2 CRKL EML4 FGF6 HNF1A LIG1 NF2 PIK3R2 RASA1 SMARCB1 TOPAZ1
ABL2 BRD3 CRTC1 EMSY FGF7 HNRNPDL LIG4 NFE2L2 PIK3R3 RB1 ‖** SMARCD1 TP53
ABRAXAS1 BRD4 CSF1R EP300 FGF8 HOXB13 LMO1 NFKBIA PIM1 RBBP6 SMARCE1 TP53BP1
ACVR1 BRIP1 CSF3R EPCAM FGF9 HRAS LRP1B NHEJ1 PIN1 RBM10 SMC1A TP63
ACVR1B BSG CTC1 EPHA3 FGFR1 #‖ HSD3B1 LRP2 NKX2-1 PKM RBMX SMC3 TP73
ACVR2A BTG1 CTCF EPHA5 FGFR2 #‖ HSP90AA1 LRP5 NOTCH1 PLCG2 RECQL SMO TPMT
ADARB2 BTG2 CTLA4 EPHA7 FGFR3 ICOSLG LRP6 NOTCH2 PLEKHS1 RECQL4 SNCAIP TRAF2
ADGRA2 BTK CTNNA1 EPHB1 FGFR4 ID3 LTK NOTCH3 PLRG1 RET SOCS1 TRAF3
ADGRG4 BUB1B CTNNB1 ERBB2# FH IDH1 LYN NOTCH4 PMS1 REV3L SOCS3 TRAF7
AFDN C9orf78 CUL3 ERBB3 FLCN IDH2 LZTR1 NOVA1 PMS2 RGS1 SOS1 TRIM24
AGGF1 CALR CUL4A ERBB4 FLT1 IDO1 MAD2L2 NPM1 POLA1 RHEB SOX10 TRIP13
AIP CARD11 CUX1 ERCC1 FLT3 IFNG MALT1 NPRL2 POLD1 RHOA SOX17 TSC1
AKT1 CASP8 CWC22 ERCC2 FLT4 IFNGR1 MAP2K1 NPRL3 POLE RHOB SOX2 TSC2
AKT1S1 CASR CXCR4 ERCC3 FOXA1 IFNGR2 MAP2K2 NRAS POLH RICTOR SOX9 TSHR
AKT2 CAV1 CYLD ERCC4 FOXL2 IFNW1 MAP2K4 NRG1 POLQ RIF1 SPEN TSHZ2
AKT3 CBFB CYP17A1 ERCC5 FOXO1 IGF1 MAP3K1 NSD1 POT1 RILPL1 SPOP TYMP
ALB CBL CYP19A1 ERCC6 FOXP1 IGF1R MAP3K13 NSD2 POU2F2 RIT1 SRC TYMS
ALK‖ CBLB CYP2C19 ERCC6L2 FRS2 IGF2 MAP4K3 NSD3 PPARG RNASEH2B SRSF2 TYRO3
ALOX12B CCAR1 CYP3A4 ERCC8 FUBP1 IGF2BP3 MAPK1 NSRP1 PPIG RNF43 SRY U2AF1
ALOX15B CCN6 DAXX EREG FUBP3 IGF2R MAPK3 NTHL1 PPM1D ROBO1 SS18 UBE2T
ALOX5 CCNA2 DCUN1D1 ERF FUS IKBKE MAPKAP1 NTRK1 PPP2CA ROBO2 STAG2 UGT1A1
AMER1 CCNB1 DDIT3 ERG FYN IKZF1 MARK2 NTRK2 PPP2R1A ROS1 STAT1 UIMC1
APC CCND1 # DDR1 ERRFI1 FZD1 IL1R1 MAX NTRK3 PPP2R2A RPA1 STAT3 ULBP1
APEX1 CCND2 # DDR2 ESR1 #‖ FZD10 IL2RA MCL1 NUMA1 PPP3CA RPS27A STAT4 ULBP3
APLNR CCND3 DDX17 ETS1 FZD2 IL2RB MDC1 NUMB PPP6C RPS6KA3 STK11 ‖** USP28
AR # CCNE1 # DDX18 ETV1 FZD3 IL2RG MDM2 NUP93 PRDM1 RPS6KB1 STK19 USP7
ARAF CCNE2 DDX27 ETV4 FZD4 IL7R MDM4 NUTM1 PREX1 RPS6KB2 STK40 USP9X
ARFRP1 CD274 DDX3X ETV5 FZD5 INHBA MED12 P2RY8 PREX2 RPTOR STN1 VEGFA
ARHGAP35 CD276 DDX41 ETV6 FZD6 INPP4B MEF2B PABPC1 PRKAR1A RRAGC SUFU VEGFB
ARID1A CD74 DEPDC5 EWSR1 FZD7 INTS6L MEN1 PAK1 PRKCI RSPO1 SYK VHL
ARID1B CD79A DEPTOR EXO1 FZD8 IRF1 MERTK PAK3 PRKDC RSPO2 SYNCRIP VIRMA
ARID2 CD79B DHX15 EZH1 FZD9 IRF2 MET ‖# PALB2 ‖** PRKN RSPO4 TACSTD2 WBP11
ASXL1 CDC27 DHX16 EZH2 GAS6 IRF4 MGA PARG PRMT5 RUNX1 TAF1L WEE1
ATM ‖** CDC5L DHX36 FAAP100 GATA1 IRS2 MITF PARP1 PRPF40B RUNX1T1 TAP1 WRN
ATMIN CDC7 DHX9 FAAP20 GATA2 JAK1 MKNK1 PARP2 PRPF4B RXRA TAP2 WT1
ATR CDC73 DICER1 FAAP24 GATA3 JAK2 MLH1 PAX3 PSENEN RYBP TAPBP WWP1
ATRX CDH1 DIS3L2 FANCA GATA4 JAK3 MLH3 PAX5 PSMB10 SAMHD1 TBC1D7 XBP1
AURKA CDH6 DLL4 FANCB GATA6 JUN MLST8 PAX7 PSMB8 SDC4 TBX3 XPA
AURKB CDK11A DNAJB1 FANCC GEN1 KAT6A MPL PAX8 PSMB9 SDHA TCERG1 XPC
AURKC CDK12 ‖** DNMT1 FANCD2 GID4 KAT6B MRAS PAXIP1 PTCH1 SDHAF2 TCF7L2 XPO1
AXIN1 CDK4 # DNMT3A FANCE GLI1 KDM4A MRE11 PBRM1 PTDSS1 SDHB TEK XRCC1
AXIN2 CDK6 # DNMT3B FANCF GNA11 KDM5A MSH2 PCBP1 PTEN ‖** SDHC TEN1 XRCC2
AXL CDK7 DOT1L FANCG GNA13 KDM5B MSH3 PCBP2 PTPN11 SDHD TENT5C XRCC3
B2M CDK8 DPYD FANCI GNAQ KDM5C MSH6 PCDH15 PTPN2 SEM1 TERT XRCC4
BABAM1 CDKN1A DUSP4 FANCL GNAS KDM6A MTAP ‖** PDCD1 PTPRD SERPINB3 TET1 XRCC5
BABAM2 CDKN1B DYNLL1 FANCM GPATCH8 KDR MTHFR PDCD1LG2 PTPRS SERPINB4 TET2 XRCC6
BAP1 CDKN1C DYRK2 FAS GPC3 KEAP1 ‖** MTOR PDE7A PTPRT SESN2 TFE3 YAP1
BARD1 CDKN2A ‖** E2F3 FAT1 GREM1 KIN MUTYH PDGFRA# QKI SETD2 TFRC YES1
BCL2 CDKN2B ECT2L FBXW7 GRIN2A KIT # MYB PDGFRB RAB35 SF3B1 TGFBR1 ZC3H13
BCL2L1 CDKN2C EFTUD2 FCGR2A GSK3B KLF4 MYC # PDK1 RAC1 SF3B3 TGFBR2 ZC3H18
BCL2L2 CEBPA EGFR #‖ FCGR3A GSTM1 KLHL6 MYCL PDPK1 RAD18 SH2D1A THRAP3 ZC3H4
BCL6 CELF4 EIF1AX FEN1 GSTP1 KLHL9 MYCN PHF6 RAD21 SHLD1 TIA1 ZMYM3
BCOR CEP295 EIF4A4 FGF1 H3-4 KMT2A MYD88 PHLPP1 RAD50 SHLD2 TIPARP ZNF217
BCORL1 CFAP20 EIF4A2 FGF10 H3F3A KMT2B MYOD1 PHLPP2 RAD51 SLC34A2 TMEM127 ZNF703
BCR CHD4 EIF4A3 FGF12 HACD4 KMT2C NAB2 PHOX2B RAD51B SLFN11 TMPRSS2 ZNRF3
BIRC5 CHEK1 EIF4B FGF14 HDAC2 KMT2D NBN PIAS4 RAD51C ‖** SLIT2 TNFAIP3 ZRSR2
BLM CHEK2 ‖** EIF4E FGF19 HDAC6 KNSTRN NCOR1 PIK3C2B RAD51D ‖** SMAD2 TNFRSF14
BMPR1A CIC EIF4E2 FGF2 HELQ KRAS # NCR1 PIK3CA # RAD52 SMAD3 TNFRSF1A
BRAF #‖ CMTM4 ELAVL1 FGF23 HES1 LATS1 NCR3 PIK3CB RAD54L SMAD4 TNK2
BRCA1 ‖** CMTM6 ELAVL2 FGF3 HEY1 LGR4 NEGR1 PIK3CD RAET1E SMARCA2 TNPO1
BRCA2 ‖** CNOT3 ELF3 FGF4 HEYL LGR5 NELFE PIK3CG RAF1 # SMARCA4 TOP1
Includes TERT promoter region.
#Includes CNAs
Includes Fusions/Rearrangements.
**Includes Copy Number Losses.
References:
1. Guardant360® CDx Technical Information. Guardant Health, Inc. Palo Alto, CA. July 2021.
2. Guardant360® Specification Sheet. Guardant Health, Inc. Palo Alto, CA. July 2024.

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